The Nigerian grabbed the opener for Leverkusen against Werder Bremen from the penalty spot, going into the half-time break.
It was 18 goals in 27 matches for Boniface, who only returned to football after four months on the sideline after his surgery on an injury he picked during the Super Eagles AFCON 2023 training camp in Abu Dhabi.
Boniface who was later replaced in the second half, watched as his teammates added four goals in the 5-0 demolition of Bremen at the BayArena.
Boniface and his countryman Nathan Tella became the third and fourth Nigerian to win the Bundesliga title.